Modulation of natural killer cell activity by viruses
نویسندگان
چکیده
منابع مشابه
Modulation of Natural Killer Cell Activity
Natural killer (NK) cells are a heterogenous subpopulation of peripheral blood lymphocytes (PBL) that have the ability to kill various tumors and tumor cell lines in the absence of prior sensitization. These cells have generated considerable interest and have been implicated in natural resistance to tumors,'-5 resistance to viral infection:-7 transplantation rejection,'** and immunoregulation o...
متن کاملHormonal modulation of human natural killer cell activity in vitro.
This study investigates the effect of steroid and polypeptide hormones on human NK cell activity in vitro. Solutions of hormones were incubated with normal peripheral blood cells in a 4 h cytotoxic assay against the NK-sensitive erythromyeloid cell line K562. The steroid hormones oestradiol, progesterone and testosterone did not exhibit a significant effect on K562 lysis at concentrations withi...
متن کاملModulation of natural killer cell anti-tumor reactivity by platelets.
Natural killer (NK) cells may prevent tumor progression and metastasis. Apart from the direct interaction with their targets, NK cell activity is influenced by the reciprocal interplay with other hematopoietic cells. While the interaction of NK cells e.g. with dendritic cells or monocytes/macrophages is well characterized, knowledge regarding their crosstalk with platelets, another central comp...
متن کاملSelective Modulation of Antibody Response and Natural Killer Cell Activity by Furine Nucleoside Analogues1
Analogues that are poor substrates for adenosine deaminase or purine nucleoside phosphorylase may mimic immunodeficiencies associated with the enzyme deficiencies, and their activities may be directed toward selected lymphocyte subpopulations. Four analogues were studied for their effects on primary antibody response to either a T-dependent (sheep erythrocytes) or T-independent (trinitrophenyl-...
متن کاملAdenosine Receptors and Modulation of Natural Killer Cell Activity by Furine Nucleosides1
Natural killer (NK) cell activity is inhibited by the adenosine analogue tubercidin (Tub) and stimulated by the deoxyadenosine analogue 2-fluorol-/9-r>-arabinofuranosyladenine S'-monophosphate (F-ara-AMP) in the spleen lymphocytes from mice treated with the drugs in vivo (T. Priebe et al.. Cancer Res., 48: 4799, 1988). The present report demonstrates that the inhibition by Tub and stimulation b...
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ژورنال
عنوان ژورنال: Current Opinion in Microbiology
سال: 2010
ISSN: 1369-5274
DOI: 10.1016/j.mib.2010.05.011